The Israeli strikes were part of a retaliatory operation after terrorists in Gaza launched a late-night rocket attack on Tel Aviv, Israel's densely populated commercial and cultural capital, marking a dramatic escalation in hostilities.
In the early hours of Friday morning the Israeli military said it was targeting "terror sites" in the Gaza Strip, striking around 100 military sites belonging to Hamas, including the main site used to manufacture standard grade rockets.
Israeli officials say that amounts to calling for the Jewish state's destruction, and accuse Hamas, the Islamist movement that runs the Gaza Strip, of orchestrating the protests.
Others pointed the finger at Islamic Jihad, the second largest militant organization in Gaza, saying the group may have been trying to disrupt efforts by Egypt to broker a truce between Hamas and Israel.
Red alert sirens were sounded after several missiles were fired from the besieged Gaza Strip towards southern and central Israel, Hebrew-language news media reported on predawn Friday.
No Israelis had been reported wounded.
Hamas, which usually claims responsibility for its military actions, denied involvement in the rocket attack on Tel Aviv and even said it had undermined its interests.
49 morts dans des attaques terroristes visant deux mosquées — Nouvelle-Zélande
Dans ce document confus de 74 pages, intitulé " Le Grand remplacement ", le tireur déclare vouloir s'en prendre à des musulmans. Les forces de l'ordre avaient imposé un bouclage du centre-ville avant de lever les mesures quelques heures plus tard.
No damage or injuries were reported.
An initial investigation revealed that the two Iran-made Fajr rockets were launched during a meeting of Hamas officials and the visiting Egyptian mediation team, which suggests that the last thing Hamas wanted at that point was provoking Israel.
It was the first such attack on the city since the 2014 Gaza war between Hamas and Israel.
It was the first time the city had been targeted since a 2014 war between Israel and Gaza militants. Israel's military said a headquarters of the militant group Hamas was among the targets. The assessment indicated that Hamas had no intention of escalating violence with Israel.
Israel responded with warplanes, which hit 100 Hamas "terror sites", a statement from the Israel Defense Force said.
Tensions between Israel and Gaza have been boiling ever since Palestinians began violent protests near Israel's border fence.
Cabinet Minister Naftali Bennett, a hard-line rival of Netanyahu's, called on the prime minister to convene a gathering of his Security Cabinet and demand the army "present a plan to defeat Hamas".