Gareth Southgate has agreed to allow Rooney a "farewell" one-off appearance to earn his 120th cap for England.
Rooney, 33, who had by that stage lost his regular starting spot at United under Jose Mourinho, was then omitted from a series of squads by manager Southgate before announcing his global retirement in August 2017, having initially targeted this year's World Cup in Russian Federation as his swansong.
Rooney has been in excellent form for DC United, scoring 12 times and laying on six assists in just 21 appearances. The arches of Wembley will be lit up in gold - the colours of his charity - for the match.
The game against the US - three days before the decisive Nations League clash with Croatia at Wembley - has been designated as a charity fund-raiser by the FA. "It's fitting the match will be against the United States of America".
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However, now Wazza will train and play for England once more in what is set to be his very final appearance in an England shirt.
He made his global debut in 2003 against Australia and scored his first goal in a 2-1 victory over Macedonia later that year in a Euro 2004 qualification game.
The friendly fixture will be called the Wayne Rooney Foundation International in support of the former Manchester United forward's charitable interests.
But despite a return to form following a move back to boyhood club Everton that saw the manager offer to recall him, he officially retired from the national team a month into the 2017-18 Premier League season. Rooney will also be training with the squad as they prepare for their Nations League game v Croatia, although he is not set to feature in that one.