Flowers has been a disappointment since being taken out of Miami.
Entering the season, Flowers, 24, was subsequently shifted to right tackle and started each of New York's first two games at the spot prior being demoted to second string ahead of Week 3.
"I think it's just kind of run its course", coach Pat Shurmur said Monday.
The release of Flowers, who had been the butt of jokes in NY for years, generated strong reactions from the Giants faithful.
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Flowers, who went from left tackle to right tackle to benched, now can seek employment elsewhere.
This season, Pro Football Focus has given Flowers a grade of 53.8, which considered average by the metric's scale, yet is the 59th-ranked score among all graded offensive tackles. "We appreciate Ereck's efforts and we just wish him the best".
The good news for Flowers is that he'll likely be a hot commodity if the Giants end up releasing him. "Sometimes a change of scenery is good".
Flowers started 48 regular-season games and one post-season game in three-plus seasons.