Meng Hongwei's wife reported him missing on Friday, the official said.
Critics suggested that Meng's election gave Beijing a chance to enlist more worldwide help in tracking down alleged economic criminals, including corrupt officials, targeted by President Xi Jinping's anti-graft campaign.
An unnamed French judicial official said Meng arrived in China at the end of September but added that there had been no news of him since.
Rights groups previously said that Beijing could use Meng's position to arrest and deport its critics overseas.
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The company says the issue differs from problems with the Prius fail-safe mode that were addressed in the 2014 and 2015 recalls. Toyota has announced that it will recall 55,519 hybrid cars in the United Kingdom as part of a 2.4 million-car global recall.
Interpol staff can carry special passports to help speed deployment in emergency situations but that would not have given Meng any specific rights or immunity in his home country.
An Interpol spokesman says the global law enforcement agency is aware of the Post's story, but would not comment on it or say if Chinese authorities had detained the 64-year-old Meng.
Before taking over at Interpol, Meng Hongwei was deputy minister in charge of public security in China.
In conclusion, Hatton asks, "If [Meng] has really gone missing within the Chinese state apparatus, who did he anger, or what could he have done for Beijing to willingly, and publicly, forfeit the top job at Interpol?".
Xi has been seeking the return of officials and businesspeople accused of fraud and corruption from overseas, sometimes with the help of Interpol in an arrangement human rights advocates say is prone to abuse.