Mahomes achieved the distinction in the 2nd quarter of the ongoing matchup against the San Francisco 49ers, where outgoing QB Alex Smith started his career.
During the second half of the 38-27 loss to Kansas City, Garoppolo tried to change directions on a run near the sideline.
With his 49ers in pursuit of a fourth-quarter comeback and driving into scoring range, Garoppolo attempted a rush towards the sidelines when it appeared that his left knee gave out before contact with the Chiefs' Steven Nelson.
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The 49ers (1-2) rallied behind running backs Matt Breida and Alfred Morris, who kept gouging the Chiefs' defensive front, and Jimmy Garoppolo, who threw for 251 yards and two scores.
Garoppolo will have an MRI on Monday to determine the severity of the injury.
Beathard said he spoke to Garoppolo briefly in the trainer's room, and what little of their exchange he was willing to repeat made it quite clear the 49ers' franchise quarterback - who signed a five-year, $137.5 million extension in February - expects his season to be over. Garoppolo is one of the bright, shining stars of the National Football League within the same generation as Andrew Luck, Patrick Mahomes, Deshaun Watson, Baker Mayfield and others. San Francisco will face the Chargers next week.
"Just like we always do, you show up to work tomorrow", Shanahan said. "If C.J.'s rolling out there, we'll be ready to go". We dealt with this with our running back, too. "He led us to our first win previous year".