His injury is a blow with 14 of City's World Cup players still to return to training, although Guardiola was impressed with his young players who fought back from two goals to beat the Bundesliga champions 3-2 on the night.
An undermanned City fell to back-to-back ICC defeats after succumbing to a 94th-minute Sadio Mane penalty in New Jersey midweek.
It was another fine performance from an undermanned and youthful City, who have been without a host of their stars following the World Cup in Russian Federation.
Mane stroked home Liverpool's victor from the penalty spot deep into stoppage time to give Jurgen Klopp's men a morale-boosting victory over an under-strength City team at the MetLife Stadium.
Manchester City midfielder David Silva says his current contract, which runs until 2020, could be his last at the Premier League champions and has ruled out a future move to any rival club in England. Guardiola meanwhile said he was relieved no players were injured.
The Egypt global, who was Liverpool's top scorer last season with 44 goals in 52 appearances across all competitions, suffered a shoulder injury in the club's Champions League final defeat by Real Madrid in May. It was the same in the previous two games - I said how proud I was.
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Eighteen-year-old Spanish forward Brahim Diaz caught the eye with a lively attacking display which he came close to capping with a goal in the 36th minute.
Club-record signing Riyad Mahrez headlined Wednesday's starting XI, with Sane and Bernardo Silva on the bench. "Still, he is far away from his best". "I don't know (the extent)".
"He has the talent to do that and we are happy that he scored. We have five or six days until the Community Shield and I don't know which players will be able to play, but I am so satisfied with these games".
Speaking in his post-game press conference, Guardiola insisted that he was happy with how his players performed on their tour of the US.
"We came here with a lot of young players and new players".
Mahrez, who arrived from Leicester City in a £60million deal, went down early under a challenge and the Algeria star failed to shake off the problem before the half-hour mark in Miami. "Now he's in ideal condition, he trains with us but we didn't want to take a risk with him on this pitch because we need players for the beginning of the season".