Real Madrid, the reigning champions, are chasing a record-extending 13th European title and a fourth win in five seasons.
Bayern Munich goalkeeper Sven Ulreich had made an nearly incomprehensible mistake to gift Benzema a goal in the semi-final, and Karius's gaffe was every bit as bad.
The German is a good shot stopper, but he is not a world-class goalkeeper, and that was emphasised by his calamitous mistake when gifting the ball to Benzema.
Gareth Bale made a game-changing impact when he was brought on to the field in the 64th minute. Madrid and Zidane had already wrapped up their very own hat-tricks by then, though.
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Bale scored an insurance goal in the 84th minute, with help from Karius.
But the Egyptian FA tweeted that Salah had his X-ray, showing he had a "sprain in the shoulder ligaments" and that it was "optimistic" he would be fit for the Russian Federation tournament, which starts on 14 June.
Salah has become the team's talisman with 44 goals this season, and the Egyptian went into the game as their number one hope of a winning outcome. Liverpool players were inconsolable at full time, needless to say, but once the pain of defeat subsides they can look back with enormous pride at their achievements in the competition this term.
Salah's exit gave Real an immediate lift because they had been nervous and edgy up until that point in the game. Dejan Lovren headed goalward from a corner and Sadio Mane nipped in front of Keylor Navas to poke home.