Celta Vigo have little left to play for after a steady campaign.
Cristiano Ronaldo and Dani Carvajal are out but Gareth Bale is starting after missing Wednesday night.
When is Real Madrid vs Celta Vigo and what time is kick-off?
Celta welcome back top scorer Iago Aspas after a month out injured on the subs' bench.
Bale burst onto Luka Modric's pass to smash home the opener just 13 minutes into the game, and doubling their lead with a fantastic goal on the half-hour mark.
Seven minutes after the re-start the impressive full-back Achraf surged on to Karim Benzema's pass and fired through the legs of the luckless Sergio.
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Even against Sunrisers, he was excellent as he scored 65 runs in 39 deliveries. Kane Williamson whips away a shot to the legside during the IPL.
Some comical Madrid defending briefly looked to have brought Celta level but Daniel Wass was in an offside position when he cut back for Maxi Gomez to finish, although Casemiro was fortunate not to be punished for bundling Brais Mendez to the floor before the ball fell to Wass.
Zidane's team continued to knock on the door down the other end though, and doubled their advantage in the 30th minute when Bale cut inside before finding the top corner with a wonderful finish.
Spanish worldwide Isco made it three with an audacious curler two minutes later to give Los Blancos a comfortable cushion heading into half-time.
The Celta goalkeeper kept out a header before the hour to deny Bale his hat-trick and the officials erred in disallowing Benzema's follow-up for offside.
And with less than 10 minutes of the regulatory 90 remaining, Kroos, who has scored more goals against the Galician outfit than any other in La Liga, heaped further misery on Juan Carlos Unzue's men after punishing yet more shoddy defending with a simple finish inside the area to round off a ideal night for Los Blancos.
However, despite already knowing they would be leaving the Spanish capital with nothing, Celta Vigo's ordeal was not over as with just over 15 minutes from time, Gomez could do little else but turn the ball into his own net after substitute Marco Asensio delivered a testing cross into the area from the left-hand byline.
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